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Dorohedoro Sequel Season Reveals Returning Staff, 2025 Debut in New Visual

The official website for the MAPPA, and that the season will stream this year.

Viz Media publishes the manga in English, and it describes the story in the first volume:

In a city so dismal it's known only as "the Hole," a clan of Sorcerers have been plucking people off the streets to use as guinea pigs for atrocious "experiments" in the black arts. In a dark alley, Nikaido found Caiman, a man with a reptile head and a bad case of amnesia. To undo the spell, they're hunting and killing the Sorcerers in the Hole, hoping that eventually they'll kill the right one. But when En, the head Sorcerer, gets word of a lizard-man slaughtering his people, he sends a crew of "cleaners" into the Hole, igniting a war between two worlds.

Yuichiro Hayashi (Fairy gone) composed the music.

The first anime season debuted on streamed the season outside Japan in May 2020.

Sources: Dorohedoro anime's website, Comic Natalie